The ERGO™ Genome Analysis System provides an in silico systems biology approach for the comprehensive analysis of organisms for which genomic DNA sequence data is available.

The ERGO™ Genome Analysis System achieves this by providing:

• Genome diversity.  ERGO™ has the largest and most diverse collection of genomes available.  More genomes from sequencing sources worldwide are constantly being loaded.  The value of useful derived genomic information increases with the number of genomes

• Gene annotations.  The ERGO™ genomes are annotated with the broadest, most integrated, and best curated set of functional gene assignments.  These assignments are made using techniques based upon biological principles regarding functional coupling of genes

• Functional content.  ERGO™ annotations connect genes through their functions to an extensive ERGO™ pathway collection. These pathways are linked together into the global ‘road-map’ or ‘wiring diagram’ that provides the best genome-level description of an organism’s metabolic and functional capabilities

• Integrated Systems Biology Data.  The ERGO™ functional content is a powerful way to analyze functional genomics data, from high-throughput expression microarrays to gene essentiality (‘knock-out’) information, providing an in silico view the systems response of the genome(s) studied

• User interactivity.  Users can navigate through the interconnected layers of genomic and functional data in ERGO™, employing public and proprietary tools to analyze genes and proteins.  Users can apply their own set of gene assignments

• Comparative genomics.  ERGO™ provides unique visual and computational tools to compare genomes based on whole-genome alignment, allowing scientists to identify unique and conserved sets of proteins between organisms, and to create occurrence profiles of sets of genes and pathways across a set of organisms