Integrated Genomics can bring a wide variety of unique microbial genomic analysis capabilities to your research teams.  Services include: 

Automated Annotation and Analysis
You are done sequencing – now, where are the genes and what do they do? Integrated Genomics automatically annotates and analyzes genomes, identifying the genes and RNAs, assigning functions to the identified proteins and RNAs, and link the functions to the network of pathways in the organism. Typically ERGO™ automated annotation results in 10% to 20% more successful function prediction than competing technologies.

Manual annotation
Reviewing and curating the automated annotation results improves the accuracy, adds more functional predictions for unassigned genes and makes additional connections to ERGO’s pathway database.  Manual annotation by IG scientists is an excellent way to refine a metabolic model for an organism by identifying missing steps in critical biochemical pathways and generate the most accurate gene functions.

Physiological analysis
Integrated Genomics’ scientists use ERGO™ to create complete metabolic reconstructions of microorganisms and work with our customers to analyze the metabolic and non-metabolic pathways to discern organism physiology.  For example, Integrated Genomics’ scientists have designed growth media for fastidious growing intracellular plant and animal pathogens.

Genome comparison
Using ERGO™, our scientists can work with you to explore the genomic basis of unique physiology and shared physiology between microorganisms or between strains.  High-resolution genome comparison can identify SNPs that affect species and strain differences. This is a particularly powerful tool for finding ways to improve production of bacterial strains and aid bioprocess development. 

Data-mining for target gene discovery
Finding unique genes for drug discovery or metabolic engineering targets is a critical start in any research project, since in silico analysis fast-tracks research and saves weeks or months of laboratory time. Data mining can also identify the genes that encode novel or useful functions in bioproduction patents.

Contact us to discuss how you can add Integrated Genomics’ world-class capabilities to your research team